Enabling Technologies
We leverage emerging technologies to get the best out of our synthetic methodologies.

We strongly believe that technology will play a pivotal role in advancing synthetic methodology throughout this century. For this reason, our research harnesses mechanochemistry, electrochemistry, and flow chemistry to develop more sustainable and industrially viable synthetic processes.
In mechanochemistry, reactions take place inside a confined ball mill jar, where mechanical forces such as grinding, milling, or shearing drive the chemistry. This unconventional technique not only reduces or eliminates solvent use—making it a greener alternative—but also enables the synthesis of molecules that are challenging to access by traditional means.
In electrochemistry, we replace hazardous chemical oxidants or reductants with heterogeneous, reusable electrodes. This approach enhances the sustainability of our protocols while improving their scalability and industrial relevance.
In flow chemistry, mass- and heat-transfer in chemical transformations are enormously improved respect to batch. Plus, reactions can be carried out in a continuous and streamlined fashion, which allows for highly efficient telescoped processes and avoids time-consuming purification of intermediates.
We strategically integrate these enabling technologies to complement and enhance our catalytic methodologies.

Using electrode to scavenge electrons

Use of 3D printing for reactor design

Using electrode to scavenge electrons
Representative publications:
F. Sacchelli, E. Quadri, L. Raineri, A. Jorea, M. Pessina, A. Lo Presti, N. Della Ca’, D. Ravelli, L. Capaldo “A Telescoped Strategy for the Preparation of Five-Membered Hetero- and Carbocycles via Hydrogen Atom Transfer Photocatalysis in Flow” ChemSusChem 2025, DOI: 10.1002/cssc.202501012
A. M. Constantin, F. Mele, M. Lanzi, G. Maestri, R. Maggi, N. Della Ca’, L. Capaldo “Mechanochemical Aerobic Activation of Metallic Copper for the Synthesis of 1,4-Allenynes” ChemSusChem 2025, 2500211, DOI: 10.1002/cssc.202500211
F. Mele, A. Aquilini, A. M. Constantin, F. Pancrazzi, L. Righi, A. Porcheddu, R. Maggi, D. A. Cauzzi, G. Maestri, E. Motti, L. Capaldo, N. Della Ca' “Mechanochemical Activation of NaHCO3: A Solid CO2 Surrogate in Carboxylation Reactions” ChemSusChem 2025, 2500461, DOI: 10.1002/cssc.202500461